Possible Mechanism Of Amyloid Formation By Apomyoglobin Mutants

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Misfolding and Amyloid Aggregation of Apomyoglobin

Apomyoglobin is an excellent example of a monomeric all α-helical globular protein whose folding pathway has been extensively studied and well characterized. Structural perturbation induced by denaturants or high temperature as well as amino acid substitution have been described to induce misfolding and, in some cases, aggregation. In this article, we review the molecular mechanism of the aggre...

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ژورنال

عنوان ژورنال: Biophysical Journal

سال: 2009

ISSN: 0006-3495

DOI: 10.1016/j.bpj.2008.12.1907